TRT is a key therapy for improving male health and quality of life in cases of testosterone deficiency. From mood and energy levels to physical fitness and sexual health, testosterone is crucial for many bodily functions in men.
A deficiency of this hormone can lead to symptoms that significantly impair quality of life. Scientists have been working on treatment options for several decades. This is precisely where Adon Health comes in: TRT offers men diagnosed with testosterone deficiency the opportunity to alleviate these symptoms and improve their quality of life. Men begin to experience declining testosterone levels from around the age of 30. The natural production of testosterone in men's bodies falls by up to 1.6% per year ( Stanworth & Jones, 2008 ). This decline is even more clearly visible in the graph:
Testosterone replacement therapy (TRT) aims to normalize testosterone levels in the body, thereby combating symptoms of testosterone deficiency. Current research shows that adequate TRT can not only alleviate the symptoms of low testosterone but also lead to improvements in physical fitness, mood, and sexual function ( Rosen et al., 2017 ). Furthermore, TRT may reduce the risk of certain health problems associated with low testosterone levels, such as cardiovascular disease and osteoporosis ( Lincoff et al., 2023 ). As with most prescription therapies, TRT is not without risks and potential side effects that must be carefully weighed against the benefits. Crucially, men considering TRT should undergo a comprehensive medical evaluation to ensure that testosterone replacement therapy is appropriate for their specific situation.
What is testosterone replacement therapy?
In a world where health and well-being are increasingly in the spotlight, testosterone replacement therapy (TRT) is at the heart of a revolutionary discussion about men's health. As a bridge between modern medicine and the body's natural balance, TRT offers a fascinating perspective on what it means to regain control over one's health.
The role of testosterone in your body
In addition to promoting muscle and bone density, testosterone plays a crucial role in regulating fat metabolism by influencing fat distribution and burning. Regarding reproductive health, testosterone is essential for sperm production and maintaining libido. Furthermore, it has a significant impact on mental health by promoting cognitive function and overall well-being. The improvement in cardiovascular health through testosterone replacement therapy (TRT), particularly in men with low testosterone levels, further underscores the systemic importance of this hormone.
Overview of TRT as a treatment method
Testosterone replacement therapy (TRT) is a medical treatment that aims to normalize testosterone levels in men with testosterone deficiency, also known as hypogonadism. Testosterone replacement therapy can be administered through various methods, including topical gels, injections, patches, and oral medications. This therapy aims to alleviate the symptoms of testosterone deficiency and can lead to an improvement in quality of life by having positive effects on mood, energy, muscle mass, bone density, and sexual function ( Corona et al., 2011 ).
Target group for a TRT
The primary target group for TRT are men with proven testosterone deficiency, accompanied by symptoms such as decreased libido, fatigue and exhaustion, loss of muscle mass, mood swings, and bone density loss. Hypogonadism is diagnosed by measuring low testosterone levels in the blood, and multiple measurements are required to confirm the diagnosis ( Bhasin et al., 2006 ).
The goals of testosterone replacement therapy (TRT) include not only treating the symptoms of testosterone deficiency but also improving quality of life. However, it is important that men with certain health conditions, such as prostate or breast cancer, cardiovascular disease, or a high risk of such conditions, are carefully evaluated for their suitability for TRT. The decision to undergo TRT should always be based on an individual assessment of the potential benefits versus the risks and made in close consultation with an experienced physician.
Symptoms and signs of testosterone deficiency
In the complexities of modern medicine, it is challenging to discern the fine lines between normal signs of aging and genuine hormonal imbalances. However, awareness of the symptoms and diagnosis of testosterone deficiency is a crucial step towards a fulfilling, healthier life.
Symptoms of testosterone deficiency
Low testosterone levels can manifest in a variety of symptoms that can significantly impair a man's quality of life. The most common signs include decreased libido, fatigue, depressed mood, sleep disturbances, a decline in muscle mass and strength, and an increase in body fat. Cognitive impairments, such as difficulty concentrating and reduced memory, can also indicate testosterone deficiency ( Sternbach, 1998 ; Smith et al., 2018 ).
How is a testosterone deficiency diagnosed?
The diagnosis of testosterone deficiency involves a careful evaluation of clinical symptoms combined with the determination of testosterone levels in the blood. A crucial step is measuring total serum testosterone first thing in the morning when testosterone levels are highest. Two tests, at least one week apart, are necessary. A comprehensive review of the medical history and physical examinations are also essential to rule out other possible causes of the symptoms and to establish a correct diagnosis ( Bhasin et al., 2018 ; Corona et al., 2011 ).
The realization that testosterone deficiency is far more than just a hormonal imbalance, but rather a reflection of a man's overall well-being, opens up new perspectives for treatment and care. It is a call to listen to our bodies' signals and to take proactive measures to address not just the symptoms, but the root cause of the problem.
The science behind TRT
Testosterone replacement therapy plays a key role in the ongoing research into men's health, not only by correcting hormonal imbalances but also by providing a new understanding of the profound effects of testosterone on the male body.
How does TRT work in the male body?
Testosterone replacement therapy (TRT) exerts its diverse positive effects on the body through various physiological mechanisms. The central aspect of TRT is the replacement of the body's own testosterone, which then acts directly on androgen receptors in the target tissues. This interaction stimulates protein synthesis, contributing to muscle growth, and also helps regulate fat distribution ( Jones et al., 2015 ). Testosterone also has effects in many other areas of the body. It is a true health booster for men, particularly in erythropoiesis. The improved production of red blood cells in the bone marrow has a direct impact on endurance and overall energy ( Mairbäurl, 2013 ). TRT also impacts mental health by contributing to improved mood and a reduction in depression, which is attributed to the neuroprotective effects of testosterone ( Corona et al., 2011 ).
Increased stamina, mental health, and libido: The benefits of TRT
Testosterone replacement therapy (TRT) can offer a wealth of potential benefits for men with low testosterone levels, extending far beyond simple hormone replacement. By restoring natural testosterone levels, men can experience improvements in various aspects of their physical and mental well-being. Healthy testosterone levels have many advantages for men. The six most important benefits of testosterone are shown in the following graphic:
Medical testosterone replacement therapy can restore many of the natural benefits of a healthy testosterone level.
Improvement of muscle mass and body composition
Testosterone plays a central role in protein synthesis, a key process for muscle growth. By binding to androgen receptors in muscle cells, testosterone promotes the uptake of amino acids into the cells, which in turn stimulates the formation of new proteins and thus muscle growth. TRT can help your body increase muscle mass and reduce body fat, thus optimizing your body composition ( Bhasin et al., 2001 ).
Increased bone density
Testosterone influences bone density through its effect on osteoblasts, the cells responsible for bone formation. It increases the production of bone matrix proteins and promotes mineralization, resulting in stronger bones. Testosterone replacement therapy (TRT) can reduce the risk of fractures, particularly in older men with an increased risk of osteoporosis ( Amory et al., 2004 ).
Improvement of sexual function
Testosterone is crucial for maintaining libido and supporting erectile function. It has a positive effect on nitric oxide (NO) synthase, an enzyme responsible for the production of nitric oxide in the blood vessels of the penis. NO is a key molecule that relaxes blood vessels and increases blood flow into the corpus cavernosum, the erectile tissue. This process leads to an erection. TRT can help increase sexual desire and improve the quality of erections ( Isidori et al., 2005 ).
Increased energy and mood
Testosterone has a significant influence on the central nervous system and contributes to the regulation of mood and energy levels. It affects the synthesis and metabolism of neurotransmitters such as serotonin and dopamine, which are responsible for feelings of well-being and energy. Testosterone replacement therapy (TRT) can help alleviate depression, improve mood, and increase overall energy levels ( Pope et al., 2003 ). In fact, a depressed mood can be a symptom of testosterone deficiency in men. We at Adon Health take your mental health seriously and know that men need a strong community and the right tools!
Improvement of cardiovascular health
Testosterone has direct and indirect effects on the cardiovascular system. It improves endothelial function. The endothelium is a thin layer of a specific cell type, the endothelial cells, that lines the inside of blood vessels. It acts as a barrier to the tissues and also produces substances such as nitric oxide. Improving this function leads to better relaxation and dilation of blood vessels, which can lower blood pressure. Furthermore, it influences lipid metabolism by increasing HDL (good cholesterol) and lowering LDL (bad cholesterol) and triglyceride levels. These changes can reduce the risk of cardiovascular disease ( Goodale et al., 2017 ). Men still often underestimate the risk of these diseases, which are already the leading cause of death. Take your cardiovascular health seriously and let's work on your health together!
Each of these benefits demonstrates how TRT goes beyond mere hormone supplementation and has the potential to significantly improve the quality of life and health of men with testosterone deficiency.
Understanding and preventing potential side effects of TRT
While TRT offers many potential benefits for men with low testosterone levels, it also carries certain risks and side effects. An objective assessment of these risks is crucial for making an informed decision about the therapy. Equally important is understanding how these risks can be minimized and managed. On your path to better health, we provide you with comprehensive and transparent information so you can make the best decision for your well-being.
Possible side effects of TRT
- Erythrocytosis: Testosterone replacement therapy can lead to an increase in red blood cells, which, when a certain threshold is reached, is called erythrocytosis. This makes the blood thicker and can increase the risk of thrombosis and embolism. However, this is primarily the case with testosterone injections, less so with the application of testosterone gels. Regular monitoring of the hematocrit level and adjustment of the testosterone dosage can help minimize this risk ( Jones et al., 2015 ). Most physicians opt for treatment with testosterone gel rather than injections.
- Effects on the prostate: Although previous assumptions that TRT increases the risk of prostate cancer have been largely refuted, the prostate should be carefully monitored before and during TRT. This includes checking PSA (prostate-specific antigen) levels and regular examinations to ensure that there are no significant changes in prostate health ( Kaplan et al., 2016 ).
- Liver health: Although testosterone replacement therapy (TRT) in the form of injections, gels, and patches typically does not have adverse effects on the liver, orally administered testosterone preparations can potentially cause liver damage. Monitoring of liver function is particularly important when using oral testosterone preparations ( Gruenewald & Matsumoto, 2003 ).
Minimizing and managing the risks of TRT
- Individual assessment: We are aware that testosterone replacement therapy must always be carried out under medical supervision. This is the only way to ensure you receive optimal care during your testosterone replacement therapy.
- Regular monitoring: Continuous monitoring of your blood count, cardiovascular health, and prostate health helps you detect potential side effects early and take appropriate action. Your doctor is always there for you during your testosterone replacement therapy!
- Dose adjustment: Adjusting the testosterone dose during TRT, based on your testosterone levels and the occurrence of side effects, helps to improve therapy safety.
- Lifestyle changes: Promoting a healthy lifestyle, including a balanced diet, regular exercise, and weight management, can further reduce the risk of side effects. In general, it's important to remember: Even before any potential therapy, you should do yourself and your health a favor and pay attention to a healthy diet, sufficient sleep, and exercise. This way, you're laying the foundation for a healthy you in the future!
Case study: From self-experimentation to structured testosterone therapy
Jonas, 39, a patient and father , had always been physically active. Strength training, a healthy diet, and a structured daily routine were important to him. Nevertheless, he noticed that he hadn't made any progress at the gym for years. He felt exhausted, and his motivation was waning—symptoms often associated with fluctuating hormones.
The risky self-experiment
Jonas kept hearing from acquaintances that testosterone brought "quick results." Without seeing a doctor, without having his testicular function or hormone levels checked, he started self-medicating. The effects were initially noticeable: more strength, better recovery, and visibly more muscle mass.
But soon side effects appeared: mood swings, skin problems, fluctuating libido, and water retention. Particularly critical was the fact that the testicles reacted to the external hormones and reduced their own production – a process that is often underestimated.
The turning point: Seeking medical help
Jonas researched online and decided to seek professional help for the first time. A blood test at a clinic revealed that his hormone levels were significantly outside the normal range and that his testicles had almost completely ceased to function.
The doctor explained the available treatment options and the importance of not relying on self-medication. Together, they started an individually tailored testosterone therapy with a clear goal: stable hormone levels, protection of bone density, and long-term health.
The structured treatment
The treatment involved Jonas coming in for regular checkups, having his hormone levels monitored in his blood, and the dosage being precisely adjusted. Patients like Jonas benefit from the fact that therapy not only improves symptoms but also minimizes health risks.
Today, Jonas is experiencing the benefits of stable testosterone therapy: more energy, better training results, and a greater sense of security in everyday life. He frequently emphasizes how important medical supervision was, in contrast to his uncontrolled self-experiment.
Why medical testosterone therapy is the better way
This example shows that patients should not jeopardize their health with uncontrolled hormones. Medically supervised therapy with clearly defined appointments, regular monitoring of testicular function and lab results offers safety and lasting effectiveness.
The combination of medical experience, medical monitoring, and the integration of lifestyle factors is crucial. This ensures that treatment remains individualized, often effective, and safe in the long term – a clear difference from risky self-experimentation.
Our conclusion, your knowledge
Testosterone replacement therapy (TRT) offers men with proven testosterone deficiency the chance for a balanced and fulfilling life. By restoring normal testosterone levels, affected men can experience significant improvements in various areas of their lives, including muscle mass, bone density, sexual function, mood, and energy levels. At the same time, it is essential to consider the potential risks and side effects of TRT and minimize them through careful medical monitoring and individualized treatment adjustments.
The importance of testosterone replacement therapy (TRT) for men with hormone deficiency cannot be overstated. It not only offers the possibility of addressing the symptoms of low testosterone but also helps reduce the risk of certain long-term health problems. However, the decision to undergo TRT must always be based on sound medical advice that prioritizes your individual health needs and risks.
The future of men's health looks promising, with a growing awareness of the significance of hormonal imbalances and the available treatment options. TRT is an integral part of this development and can offer us men the opportunity to actively improve our own health and quality of life.
