Topical hormone therapy
Testosterone gel is a widely used form of testosterone replacement therapy (TRT) . Applied daily to the skin, it penetrates the skin barrier and enters the bloodstream, thereby increasing testosterone levels. For men with a confirmed testosterone deficiency , the gel offers a convenient alternative to depot-based therapy.
Unlike long-acting injections, the gel allows for more finely tuned dosing and daily monitoring, which is particularly helpful for sensitive patients or at the start of therapy.
When is testosterone gel used?
Testosterone gel is prescribed when a doctor has diagnosed hypogonadism requiring treatment, i.e.:
- Typical symptoms include exhaustion, lack of libido, muscle loss, or low mood.
- Two morning blood tests revealed testosterone levels that were too low (below 12.1 nmol/l).
- Other causes such as thyroid disorders or mental illnesses are unlikely.
- There are no contraindications such as prostate cancer, breast cancer in men, or severely elevated hematocrit.
Men who are unsure whether they are eligible for TRT can conveniently measure their hormone levels from home using the TRT Check from Adon Health and then have them medically evaluated.
How is the gel applied?
The application is simple, but consistent:
- Apply every morning (ideally always at the same time)
- Apply to clean, dry, unbroken skin , e.g. shoulders, upper arms or abdomen
- Allow to dry for at least 5-10 minutes after application.
- Don't forget to wash your hands
- Avoid skin-to-skin contact at the application site for several hours, especially with women and children.
The dosage is usually 20–50 mg of testosterone per day, in 1–2 pumps, depending on the preparation (e.g., Testogel®, Testavan®, Androgel®). The exact amount and product selection are determined individually by the doctor.
Advantages of testosterone gel
- Easy application without injections
- Daily dose controllability
- Rapid onset of action; first effects often noticeable within 1–2 weeks.
- No spikes like with injections
- Traceability : In case of intolerance, the therapy can usually be stopped immediately.
Potential disadvantages & risks
Despite its advantages, the gel also has critical aspects that men should be aware of:
- Risk of transmission through skin contact with others, especially partners, children or pets.
- Skin irritations (itching, redness, dryness)
- Absorption varies depending on skin type, body fat percentage, and daily condition.
- Daily discipline required
Furthermore, as with any TRT, certain precautions apply: Regular monitoring of hematocrit, PSA level, testosterone level, estradiol level and medical supervision are essential.
For whom is the gel particularly suitable?
- Men with mild to moderate hypogonadism
- Patients who do not want injections or cannot tolerate them
- Men with changing lifestyles or travel who require flexibility
- Beginners, for whom the dosage should be adjusted slowly
How is the effect monitored?
The effectiveness of the treatment is monitored through regular laboratory tests . The first test should take place approximately 6 weeks after the start of therapy, and thereafter every 3–6 months.
- Testosterone (total & free)
- SHBG
- Hematocrit (to prevent blood thickening)
- PSA (prostate cancer screening)
- Liver and kidney values
The TRT check from Adon Health includes many of these markers directly. The evaluation is performed by medical experts specializing in men's health.
Additional tips on the effect
- Avoid alcohol and cigarettes, both reduce absorption and effectiveness.
- Strength training and exercise increase the natural testosterone effect
- Sleep and stress reduction promote hormonal balance.
- Make sure you get enough zinc, vitamin D, and magnesium in your diet.
- Avoid wearing tight clothing immediately after application.
Conclusion
Testosterone gel is an effective and practical form of testosterone replacement therapy, especially for men who prefer a non-invasive application. It allows for a consistent hormone release and flexible dosage, but requires correct application and regular medical monitoring. When indicated, it can significantly alleviate symptoms of testosterone deficiency and restore hormonal balance.
