When everyday life becomes a burden
Many men suffer from chronic fatigue, decreased motivation, mood swings, or concentration problems. What may initially seem like everyday stress can actually be caused by a testosterone deficiency. However, this often goes undetected, partly because men are less likely to discuss health problems. Observations from clinical practice and studies show that targeted testosterone replacement therapy (TRT) can address this issue and contribute to an improved quality of life.
Internal analyses at Adon Health indicate that men report subjective improvements just a few weeks after starting therapy. This trend appears to intensify over time.
These groundbreaking initial internal findings align with published literature on improving quality of life during testosterone therapy. Saad et al. (2011) demonstrate that initial positive effects on libido, mood, and energy levels can occur after just one month. Improvements in physical performance and overall well-being are also evident after two months. These effects continue to build and often reach their full potential only after six months. More recent studies confirm these findings: For example, a meta-analysis by Nian et al. (2017) documents significant improvements in health-related quality of life in hypogonadal men during the course of therapy.
Internal evaluation: Subjective improvements during the course of therapy
As part of an anonymized analysis, Adon Health evaluated initial feedback from men who sought medical treatment from independent partner physicians via our platform. The data, based on validated questionnaires regarding symptom burden, shows the following trends:
- After 4 weeks, 68.7% of participants reported a subjective improvement, on average by 27.1%.
- After 4 months, all participants surveyed reported a subjective improvement, averaging 39.8%.
- After 7 months, the average subjective symptom improvement was 47.7%.
These results are from an internal, exploratory data collection and serve as initial guidance. They are not equivalent to clinical trials and do not allow for general conclusions regarding effectiveness.
What happens during testosterone therapy?
Testosterone therapy is an option for diagnosed deficiency and aims to restore testosterone levels to a healthy range. In selected patients, it can lead to an improvement in symptoms such as fatigue, loss of libido, or difficulty concentrating. This therapy is administered exclusively under medical supervision and based on current medical guidelines.
For a comprehensive overview of the process, medical principles and applications of TRT, please see our article: Testosterone Replacement Therapy: Everything you need to know .
How can therapy be made possible with the help of Adon Health?
Adon Health provides diagnostic tests via a digital platform and enables the structured collection of relevant health data. Users can document symptoms, perform lab tests at home, and receive a clearly presented overview of their results.
Subsequent medical care is provided by independent, licensed physicians trained in the treatment of hormonal disorders. Adon Health does not provide medical treatment but offers organizational support and the technical infrastructure to enable efficient and transparent monitoring of progress.
Medical care is provided based on established medical guidelines, including the recommendations of the European Association of Urology.
You can find more information about the process here: Our solution at Adon Health .
Men's health, a topic with great potential
Men's hormonal health still receives too little attention, both in society and in everyday medical practice. Many affected men live with limitations without having the underlying causes investigated. Yet access to well-founded hormone replacement therapy (HRT) is not only medically relevant, but also a crucial component of modern healthcare.
Digital services like those offered by Adon Health lower the barriers to professional assessment and reach men where traditional healthcare solutions often reach their limits. The results of the internal analysis provide initial insights into potential developments in the course of therapy and underscore the potential of digitally supported solutions.
Conclusion: Potential of structured testosterone therapy
Initial evaluations show that many men subjectively report improvements in their symptoms. Scientific studies also support the assumption that targeted TRT can improve quality of life (Nian et al., 2017; Saad et al., 2011; Almehmadi et al., 2016). Crucially, this requires medical supervision in accordance with current guidelines, such as those of the EAU (2023).
Adon Health enables access to such care digitally, in a structured, medically supervised manner and flexibly integrated into everyday life.
Bibliography
Almehmadi, Y., Yassin, AA, Nettleship, JE, & Saad, F. (2016). Testosterone replacement therapy improves the health-related quality of life of men diagnosed with late-onset hypogonadism. Arab Journal of Urology, 14 (1), 31–36. https://doi.org/10.1016/j.aju.2015.10.002
Nian, Y., Ding, M., Hu, S., He, H., Cheng, S., Yi, L., Li, Y., & Wang, Y. (2017). Testosterone replacement therapy improves health-related quality of life for patients with late-onset hypogonadism: a meta-analysis of randomized controlled trials. Andrologia, 49 (4), e12630. https://doi.org/10.1111/and.12630
Saad, F., Aversa, A., Isidori, AM, Zafalon, L., Zitzmann, M., & Gooren, L. (2011). Onset of effects of testosterone treatment and time span until maximum effects are achieved. European Journal of Endocrinology, 165 (5), 675-685. https://doi.org/10.1530/EJE-11-0221
Salonia, A., Bettocchi, C., Carvalho, J., Corona, G., Jones, TH, Kadioglu, A., ... & Vardi, Y. (2023). EAU Guidelines on Sexual and Reproductive Health, Male Hypogonadism. In: European Association of Urology . https://uroweb.org/guidelines/male-hypogonadism
