Testosterone – More Than Just “Muscles & Masculinity.” In this episode, Dr. Jonathan Apasu talks with urologist and hormone expert Dr. Nicole Weirich about why many men suffer from fatigue, loss of libido, sleep problems, or decreased performance despite “normal” blood test results, and how to accurately diagnose and treat these issues. We delve deep: from the difference between total and free testosterone, through SHBG, LH/FSH, and prolactin, to primary vs. secondary (functional) hypogonadism. We also cover: fertility and TRT, gel vs. injection (including Nebido), the stress axis (cortisol/DHEA), progesterone for better sleep, insulin resistance, visceral abdominal fat and aromatase, natural vs. pharmaceutical aromatase inhibitors, liver detoxification (phases 1 & 2), estrobolome, fiber and fermented foods, as well as practical nutritional hacks (glycemic index and food order).
Topics in this episode:
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Getting diagnostics right: Total vs. free testosterone, SHBG, LH/FSH, prolactin
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Primary vs. functional deficiency: testes, pituitary gland, stress, sleep, nutrition
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Therapy: Safely dose TRT, gel vs. injection, avoid peaks, monitoring
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Fertility and desire to have children while on TRT - what is realistic
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Stress management: DHEA, progesterone & sleep quality
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Insulin resistance, belly fat & aromatase: why diet injections + proteins + strength training work
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Targeted support for the liver (B vitamins, bitter substances) and intestines (estrobolome, beta-glucuronidase).
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Everyday levers: Reduce GI, sugar/wheat, fermented foods & fiber
If you want to understand how to holistically manage your hormone balance and regain your strength – listen in! 🎧



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