Testosterone is about more than “muscles & masculinity.” In this episode, Dr. Jonathan Apasu talks with urologist and hormone expert Dr. Nicole Weirich about why many men suffer from fatigue, loss of libido, sleep problems, or drops in performance despite “normal” blood test results—and how to diagnose and treat these issues properly. We take a deep dive: from the difference between total and free testosterone to SHBG, LH/FSH, and prolactin, as well as primary vs. secondary (functional) hypogonadism. Plus: fertility and TRT, gel vs. injections (including Nebido), the stress axis (cortisol/DHEA), progesterone for better sleep, insulin resistance, visceral belly fat and aromatase, natural vs. pharmaceutical aromatase inhibitors, liver detoxification (phases 1 & 2), the estrobolome, fiber and fermented foods, as well as practical nutrition hacks (GI and “food sequencing”).
Topics covered in this episode:
-
Getting the diagnosis right: total vs. free testosterone, SHBG, LH/FSH, prolactin
-
Primary vs. functional deficiency: testes, pituitary, stress, sleep, nutrition
-
Treatment: dosing TRT safely, gel vs. injection, avoiding peaks, monitoring
-
Fertility and having children on TRT—what’s realistic
-
Stress management: DHEA, progesterone & sleep quality
-
Insulin resistance, belly fat & aromatase: why weight-loss injections + protein + strength training work
-
Targeted support for the liver (B vitamins, bitter compounds) & gut (estrobolome, beta-glucuronidase)
-
Everyday tools: glycemic index, reducing sugar/wheat, fermented foods & fiber
If you want to understand how to take a holistic approach to getting your hormones in balance and feel like yourself again, tune in! 🎧
Spotify
Apple Music
YouTube
